OBIO® drives AI innovation in critical care with The Ottawa Hospital’s use of the Extubation Advisor
October 29, 2025 (Toronto, ON) – OBIO®, through its Life Sciences Critical Technology and Commercialization (LSCTC) Centre for Excellence, is supporting the adoption of the Extubation Advisor (EA) at The Ottawa Hospital (TOH). Developed by Canadian company Therapeutic Monitoring Systems Inc. (TMS), this AI-powered clinical support tool is designed to assist clinicians in making extubation decisions in intensive care units.
A was adopted after successful evaluations were completed at TOH and Unity Health through OBIO’s Early Adopter Health Network (EAHN™) program. EAHN™ is supported by the Government of Canada, through the Federal Economic Development Agency for Southern Ontario (FedDev Ontario), and LSCTC is supported by the Government of Ontario.
Removing a patient from mechanical ventilation, which is known as extubation, is a complex process in critical care. The EA, based on research led by Dr. Andrew JE Seely, a thoracic surgeon and Intensive Care Unit (ICU) physician at TOH and CEO of TMS, uses AI to analyze patient-specific respiratory data and help clinicians with extubation decision making. This reduces uncertainty by identifying patients at higher or lower risk of extubation failure, leading to better patient outcomes and more efficient use of ICU resources.
“This tool represents more than a decade of research into how patient data can guide better care,” said Dr. Seely, CEO of Therapeutic Monitoring Systems Inc. (TMS) and Chief of Thoracic Surgery at TOH. “Extubation decisions are some of the most difficult ones we make in the ICU, and the Extubation Advisor gives clinicians access to real-time, evidence-based predictions to help guide those moments. We’re grateful to OBIO® for helping translate research into practice in a way that has the potential to benefit patients across Canada and internationally.”
TOH is one of the first hospitals to implement the EA as part of a real-world evaluation. The technology complements existing clinical judgment by offering personalized, data-driven insights that may help reduce ICU stays and minimize complications related to ventilation.
“The Ottawa Hospital continues to lead in medical innovation, and the Extubation Advisor is a strong example of how we are using technology to enhance care in the ICU,” said Dr. Kwadwo Kyeremanteng, Chair of Critical Care at The Ottawa Hospital. “By supporting more informed and individualized decisions, this tool has the potential to improve patient outcomes and make our system more efficient.”
The EA has received regulatory clearance from both Health Canada and the European Union. TMS is now working with additional healthcare partners in Canada and internationally to expand and broadly adopt its use.
“This partnership with The Ottawa Hospital and Therapeutic Monitoring Systems is a powerful demonstration of how made-in-Ontario AI-powered tools can be successfully integrated into critical care to improve patient outcomes,” said Dr. Maura Campbell, President and CEO of OBIO®. “Through our EAHN™ and LSCTC programs, we are proud to have supported the evaluation and adoption of the Extubation Advisor, showcasing our commitment to translating cutting-edge research into real-world healthcare solutions that enhance clinical decision-making and make our hospital systems more efficient.”
“Congratulations to OBIO®, The Ottawa Hospital, and Therapeutic Monitoring Systems on this important milestone,” said the Honourable Evan Solomon, Minister of Artificial Intelligence and Digital Innovation and Minister responsible for the Federal Economic Development Agency for Southern Ontario. “The Extubation Advisor is a Canadian-made, AI-powered technology that is improving patient care. Our government will continue to support partnerships that translate research into real-world solutions, ensuring Canada remains a leader in health innovation.”
About Therapeutic Monitoring Systems Inc.
Therapeutic Monitoring Systems (TMS), a Canadian Corporation operating in Ottawa, Ontario, Canada, develops regulatory-approved predictive clinical decision support software (CDSS) tools.
TMS transforms the way patient monitoring data is used in order to markedly improve patient care, by turning waveforms (e.g. electrocardiography) into variability (using variability analysis) into predictive CDSS tools (using AI machine learning), then implemented at the bedside of acutely ill patients in the Intensive Care Unit (ICU) and the Emergency Department (ED).
TMS patented software technology combines waveform processing, variability analysis and predictive modelling to transform routinely collected waveforms (that are routinely otherwise discarded) into a measure of an individual patient’s risk of subsequent deterioration. TMS provides predictive clinical decision support at the bedside in a targeted manner to address unsolved problems, as reduced variability offers a sensitive measure of a patient’s severity of illness and/or frailty. TMS CDSS tools are integrated with the existing care delivery processes, thus offering clinical decision support at the time when clinicians are making a decision. TMS CDSS tools are designed to enhance effectiveness of treatment plans and reduce harmful and costly adverse events.
TMS partners with OBS Medical, the Ottawa Hospital Research Institute (OHRI), clinicians and scientists globally to research, develop and commercialize this novel technology, to help transform monitoring and improve care.
To learn more, visit: therapeuticmonitoring.com.
About The Ottawa Hospital
The Ottawa Hospital (TOH) is one of Canada’s top learning and research hospitals where we are guided by our vision to provide the world-class and compassionate care we would all want for our loved ones. Our multi-campus hospital, affiliated with the University of Ottawa, is home to the Regional Trauma Centre and Cancer Centre, and to discoveries that are adopted globally.
All researchers at The Ottawa Hospital follow a Responsible Innovation framework for developing and commercializing innovations in a responsible way.
Backed by generous support from the community, we are focused on reshaping the future of health care to improve the health of our diverse population of patients from Eastern Ontario, Western Quebec, and Nunavut.
For more information about The Ottawa Hospital, visit OttawaHospital.on.ca.
About OBIO®
OBIO®, a not-for-profit, membership-based organization dedicated to advancing health technology innovation and commercialization, evaluates new technologies through its Early Adopter Health Network (EAHN™), supported by the Federal Economic Development Agency for Southern Ontario (FedDev Ontario), and implements successful solutions using critical technologies through its Life Sciences Critical Technologies and Commercialization (LSCTC) Centre of Excellence, supported by the Government of Ontario. OBIO® is engaged in strategy, programming, policy development and advocacy to further the commercialization of human health technologies, positioning Canada as a leader in the international marketplace. For more information, please visit OBIO.ca and follow OBIO® on LinkedIn and X.
About FedDev Ontario
For 16 years, the Government of Canada, through FedDev Ontario, has worked to advance and diversify the southern Ontario economy through funding opportunities and business services that support innovation, growth and job creation in Canada’s most populous region. The Agency has delivered impressive results, which can be seen in southern Ontario businesses that are creating innovative technologies, improving productivity, growing revenues, creating jobs, and in the economic advancement of communities across the region. Learn more about the impact the Agency is having in southern Ontario by exploring our investment profiles, our Southern Ontario Spotlight, and FedDev Ontario’s X, Facebook, Instagram and LinkedIn accounts.
Media Contacts:
Dr. Andrew Seely
CEO
Therapeutic Monitoring Systems Inc.
aseely@therapeuticmonitoring.com
Rebecca Abelson
Media Relations Officer
The Ottawa Hospital
rabelson@toh.ca
343-576-0259
Doriane Rey
Senior Manager, Marketing & Communications
OBIO®
dorianerey@obio.ca
Sofia Ouslis
Press Secretary
Office of the Minister of Artificial Intelligence, Digital Innovation and Minister responsible for the Federal Economic Development Agency for Southern Ontario
sofia.ouslis@ised-isde.gc.ca