Applications open for CACHE Challenge #8: Finding ligands targeting GID4
Applications are now open for CACHE Challenge #8, which invites participants to identify chemically novel molecules that bind to the substrate-recognition pocket of GID4, a protein involved in cellular protein quality control.
GID4 plays a role in the cell’s protein disposal system: it recognizes specific proteins that are damaged or no longer needed and directs them to the cellular protein degradation system. By selectively engaging this recognition process, researchers can potentially harness the cell’s own machinery to remove disease-causing proteins.
